RAF Typhoon FGR4s have conducted a mission with French warplanes in a joint strike against an underground arms cache in Syrian territory operated by the IS group, per a report from the UK's MoD.
The site, pinpointed through reconnaissance, was believed to be storing arms and explosives, the announcement noted, and was located in mountains just to the north of Palmyra in the heart of Syria.
"The RAF jets employed Paveway IV guided bombs to strike a number of approach shafts down to the facility... initial indications indicate the objective was successfully hit," the ministry announced.
There was no indication of any civilian impact in the attack conducted Saturday night and all the aircraft returned to base without incident, the MoD added.
The Typhoon fighters were supported by a Voyager refuelling tanker.
Daesh - alternatively referred to as ISIS - established extremist governance over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This action shows the UK's leading role, and resolve to stand shoulder to shoulder with our partners, to stamp out any resurgence of IS and their harmful and extremist ideologies in the region," the British Defence Secretary the minister remarked.
RAF aircraft have carried out patrols over Syria to "forestall any attempted resurgence" of IS following its routing at the battle of Baghuz in 2019, the ministry said.
"I want to thank every member of British forces who took part in this strike for their professionalism and their bravery," the Defence Secretary said. "They were among thousands of British personnel deployed over the holidays. This operation, to eliminate terrorist threats who pose a risk to our security, highlights how our armed forces are ready to step up, continuously, protecting the UK within its borders and powerful internationally."
In December, the American forces carried out what it called a "major assault" on IS targets in the country, after an assault killed two US servicemembers and a local interpreter in Palmyra.
The United Nations estimates Islamic State still boasts between 5,000 and 7,000 militants in Iraq and Syria.